SUNY, Stony Brook Study of SmartMouth Anti-Halitosis Treatment Rinse. In a double blind clinical trial, the efficacy of a test mouthwash containing zinc and sodium chlorite (SmartMouth Rinse) in reducing intrinsic oral malodor was compared to that of a zinc-containing OTC mouthrinse and a water control. Forty-eight subjects completed the study, 16 in the test group, 17 in the OTC group and 15 in the water group. At baseline and after 2 and 4 weeks, parameters assessed were (i) resting whole saliva odor organoleptically (both head space and liquid phase) (ii) breath VSC with a sulfide monitor (Halimeter) (iii) saliva indole/skatole levels colorimetrically with Kovac's reagent and (iv) saliva Eh with a Pt electrode. VSC, Eh and indole/skatole data were analyzed by repeated measures ANOVA between groups and by 2-way ANOVA within groups. Organoleptic data were analyzed by K-Wallis and Freidman non-parametric tests. VSC, organoleptic and Eh evaluations showed the test mouthrinse to be much more effective than the other two rinses (p<0.001 between test mouthrinse and water and P<0.001, <0.05, <0.01 between test mouthrinse and OTC product for VSC, organoleptic and Eh tests, respectively by the end of the study). In fact, the organoleptic headspace score was reduced to zero and VSC levels below 50 ppb S, a level where the breath is non-odorous The test mouthwash also appeared more effective in reducing indole/skatole, but the results did not reach significance VSC correlated significantly with all measured parameters. Zinc plus sodium chlorite in a mouthrinse was much more effective in reducing oral malodor than one with zinc alone or water.